https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Neonatal immune activation depletes the ovarian follicle reserve and alters ovarian acute inflammatory mediators in neonatal rats https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33905 Tnfa, mitogen-activated protein kinase 8 (Mapk8/Jnk1), and growth differentiation factor 9 (Gdf9) (P < 0.05). Mass spectrometry and cell signaling pathway analysis indicated upregulation of cellular pathways associated with acute phase signaling, and cellular survival and assembly. Apoptosis assessed by terminal deoxynucleotidyl transferase dUTP nick end labeling indicated significantly increased positive staining in the ovaries of LPS-treated neonates. These findings suggest that increased proinflammatory signaling within the neonatal ovary may be responsible for the LPS-induced depletion of the primordial follicle pool. These findings also have implications for female reproductive health, as the ovarian reserve is a major determinate of female reproductive longevity.]]> Wed 09 Feb 2022 15:58:52 AEDT ]]> Endocrine disruptor compounds -a cause of impaired immune tolerance driving inflammatory disorders of pregnancy? https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39107 Tue 10 May 2022 10:00:40 AEST ]]> A review of fundamental principles for animal models of DOHaD research: an Australian perspective https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37562 Thu 26 May 2022 15:47:23 AEST ]]>